Journal
CLINICAL IMMUNOLOGY
Volume 197, Issue -, Pages 77-85Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2018.09.005
Keywords
Type 2 diabetes; Obesity; Th17 cell; Treg cell
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Funding
- National Natural Science Foundation of China [81100581]
- Bethune Merck Diabetes Research Fund [2018]
- Cardiac rehabilitation and metabolic therapy research fund [2018]
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Assumption that the pathogenesis of obesity-associated type 2 diabetes (T2DM) encompasses inflammation and autoimmune aspects is increasingly recognized. In the state of obesity and T2DM, the imbalance of T helper 17 (Th17) cells and regulatory T (Treg) cells are observed. These alterations reflect a loss of T cell homeostasis, which may contribute to tissue and systemic inflammation and immunity in T2DM. In this review we will discuss the accumulating data supporting the concept that Th17/Treg mediated immune responses are present in obesity-related T2DM pathogenesis, and provide evidences that restoration of Th17/Treg imbalance may be a possible therapeutic avenue for the prevention and treatment of T2DM and its complications.
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