Journal
CLINICAL IMMUNOLOGY
Volume 153, Issue 1, Pages 156-164Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2014.04.006
Keywords
Myeloid-derived suppressor cells; T cell suppression; Type 1 diabetes mellitus
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Funding
- Doris Duke Charitable Foundation Young Investigator Award [2011045]
- North Carolina Translational and Clinical Sciences (NCTraCS) Clinical and Translational Research Center
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Type 1 Diabetes Mellitus (T1D) results from the destruction of insulin-producing beta cells in the pancreas by autoreactive T cells. Myeloid derived suppressor cells (MDSCs) are a recently identified immune cell subset that down-regulate T cells. Whether defects in MDSC numbers or function may contribute to T1D pathogenesis is not known. We report here that MDSCs are unexpectedly enriched in peripheral blood of both mice and patients with autoimmune diabetes. Peripheral blood MDSCs from T1D patients suppressed T cell proliferation in a contact-dependent manner; however, suppressive function could be enhanced with in vitro cytokine induction. These findings suggest that native T1D MDSCs are not maximally suppressive and that strategies to promote MDSC suppressive function may be effective in preventing or treating T1D. (C) 2014 Elsevier Inc. All rights reserved.
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