Journal
CLINICAL IMMUNOLOGY
Volume 155, Issue 1, Pages 136-147Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2014.09.009
Keywords
Hygiene hypothesis; Newborn infant; Cord blood; Gene expression; Innate immunity; Immune adaptation
Categories
Funding
- European Commission [EC-FP7-DIABIMMUNE-202063, EC-FP7-SYBILLA-201106, EC-FP7-NANOMMUNE-214281, EC-FP7-PEVNET-261441]
- Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research) [250114, 77773, 203725, 207490, 116639, 115939, 123864, 126063]
- Sigrid Juselius Foundation
- Juvenile Diabetes Research Foundation (JDRF)
- Turku University Hospital Research Fund
- Oskar Oflund Foundation
- Academy of Finland (AKA) [123864, 116639, 203725, 126063, 207490, 77773, 115939, 123864, 116639, 207490, 126063, 115939, 77773, 203725] Funding Source: Academy of Finland (AKA)
Ask authors/readers for more resources
The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in the developed world. In order to explore differences in the gene expression patterns induced in utero in infants born in contrasting standards of living and hygiene, we collected umbilical cord blood RNA samples from infants born in Finland (modern society), Estonia (rapidly developing society) and the Republic of Karelia, Russia (poor economic conditions). The whole blood transcriptome of Finnish and Estonian neonates differed from their Karelian counterparts, suggesting exposure to toll-like receptor (TLR) ligands and a more matured immune response in infants born in Karelia. These results further support the concept of a conspicuous plasticity in the developing immune system: the environmental factors that play a role in the susceptibility/protection towards immune-mediated diseases begin to shape the neonatal immunity already in utero and direct the maturation in accordance with the surrounding microbial milieu. (C) 2014 The Authors. Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available