Journal
CLINICAL IMMUNOLOGY
Volume 153, Issue 1, Pages 23-30Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2014.03.016
Keywords
Type 1 diabetes mellitus; CD4+CD25+T regulatory cells; Tregs; Immunotherapy
Categories
Funding
- National Centre for Research and Development [NR13-0126-10]
- Polish Ministry of Science [IP2011 033771]
- National Centre of Science [DEC-2011/01/D/NZ3/00262]
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It is hypothesized that CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) can prevent destruction of pancreatic islets protecting from type 1 diabetes (DM1). Here we present results of one year follow-up of 12 DM1 children treated with autologous expanded ex vivo Tregs. Patients received either a single or double Tregs infusion up to the total dose of 30 x 10(6)/kg. No severe adverse effects were observed. The treatment did not impair post-immunization antibody responses. Tregs infusion was followed by increase in Tregs number in peripheral blood. Most of the patients responded to the therapy with increase in C-peptide levels (8/12 and 4/6 after the first and the second dose, respectively). Tregs administration resulted also in lower requirement for exogenous insulin (8/12 treated patients versus 2/10 untreated controls in remission) with two children completely insulin independent at one year. Repetitive administration of Tregs is safe and can prolong survival of beta-cells in DM1 (registration: ISRCTN06128462). (C) 2014 Elsevier Inc. All rights reserved.
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