Journal
CLINICAL IMMUNOLOGY
Volume 148, Issue 1, Pages 16-26Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2013.03.012
Keywords
Cytomegalovirus; T-lymphocyte; Immune activation; Lung transplantation; Acute rejection
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Funding
- Vaincre la Mucoviscidose (VLM)
- National Institutes of Allergy and Infectious Diseases
- Fondation pour la Recherche Medicate (FRM)
- Wellcome Trust [100326/Z/12/Z] Funding Source: researchfish
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Lung transplantation is the definitive treatment for terminal respiratory disease, but the associated mortality rate is high. Acute rejection of the transplanted lung is a key determinant of adverse prognosis. Furthermore, an epidemiological relationship has been established between the occurrence of acute lung rejection and cytomegalovirus infection. However, the reasons for this association remain unclear. Here, we performed a longitudinal characterization of CMV-specific T-cell responses and immune activation status in the peripheral blood and bronchoalveolar lavage fluid of forty-four lung transplant patients. Acute rejection was associated with high levels of cellular activation in the periphery, reflecting strong CMV-specific CD8(+) T-cell activity post-transplant. Peripheral and lung CMV-specific CD8(+) T-cell responses were very similar, and related to the presence of CMV in the transplanted organ. These findings support that activated CMV-specific CD8(+) T-cells in the lung may play a role in promoting acute rejection. (C) 2013 Elsevier Inc. All rights reserved.
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