Journal
CLINICAL IMMUNOLOGY
Volume 144, Issue 3, Pages 250-268Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2012.06.003
Keywords
MDSC; Cancer; Autoimmunity; Transplantation
Categories
Funding
- Karolinska Institutet
- Cancerfonden
- Cancerforeningen
- Lars Hiertas memorial foundation
- Robert Lundberg fund
- Sigurd och Elsa Goljes memorial foundation
- Jubileumsfonden
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Myeloid-derived suppressor cells (MDSC) have frequently been observed in patients with cancer. This heterogeneous population of myeloid cells can exert potent suppression of lymphocyte function and thereby poses a significant hurdle to natural or therapeutically induced anti-tumor immunity. On the other hand, the natural function of MDSC is not yet well understood and their role in infection, inflammation and autoimmune disease is still puzzling. Understanding MDSC biology will provide the tools necessary for therapeutic targeting of this population, but also permit exploitation of their strong tolerogenic function in the treatment of inflammatory conditions and the prevention of graft rejection. (C) 2012 Elsevier Inc. All rights reserved.
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