Journal
CLINICAL IMMUNOLOGY
Volume 141, Issue 3, Pages 253-267Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2011.09.002
Keywords
Naive T-cells; HIV-1; IL-7; Immune reconstitution; Antiretroviral therapy; Reservoirs
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Funding
- National Health and Medical Research Council (NHMRC)
- Alfred Foundation
- Malaysian government
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Functional naive T-cells are critical for an effective immune response to multiple pathogens. HIV leads to a significant reduction in CD4+ naive T-cell number and impaired function and there is incomplete recovery following combination antiretroviral therapy (cART). Here we review the basic homeostatic mechanisms that maintain naive CD4+ T-cells and discuss recent developments in understanding the impact of HIV infection on naive CD4+ T-cells. Finally we review therapeutic interventions in HIV-infected individuals aimed at specifically enhancing recovery of naive CD4+ T-cells. (C) 2011 Elsevier Inc. All rights reserved.
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