Journal
CLINICAL IMMUNOLOGY
Volume 134, Issue 3, Pages 305-312Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2009.11.004
Keywords
Type I autoimmune hepatitis; Paediatric and adult patients; Transforming Growth Factor-beta 1; TGF-beta 1; Interleukin 10; IL-10; Single nucleotide polymorphisms; SNPs; HLA associations
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Funding
- ANPCyT PICT 2004 [25296]
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We previously reported that paediatric (PAH) and adult (AAH) forms of type I autoimmune hepatitis (AH) have different HLA-associations and clinical outcome. In the present study we investigated the role of TGF-beta 1 genetic polymorphisms in the different outcome of PAH and AAH. We found a significant increase of high producer 25GG genotype in PAH and 10CC in AAH. Low inflammation and low fibrosis in AAH was associated with the increase of codon 10CC (high producer) and codon 25CC (tow producer) genotypes. The analysis in AAH of the two positions-haplotypes revealed that combined presence of 25GG and 10CC seems to neutralize the 10CC effect which remained in AAH having the 10CC(+)-25GG(-) haplotype. Altogether these results may explain, at least partially, the different clinical outcome of AAH and PAH. Published by Elsevier Inc.
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