Journal
CLINICAL IMMUNOLOGY
Volume 137, Issue 2, Pages 288-295Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2010.07.012
Keywords
Tim-3; Rheumatoid arthritis; Disease activity score 28; TNF-alpha
Categories
Funding
- National Nature Science Foundation of China [30972753]
- National Basic Research Program [2009CB521900]
- Independent Innovation Foundation of Shandong University (IIFSDU)
- Shandong Provincial Nature Science Foundation [JQ200907]
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Tim-3 has been reported as an important regulatory molecule and plays a pivotal role in several autoimmunity diseases. Here, we demonstrated the increased expression of Tim-3 on peripheral CD4(+) T, CD8(+) T, NKT cells and monocytes from RA patients compared to those from healthy controls. Percentage of Tim-3(+) cells in peripheral blood mononuclear cells (PBMCs) showed an inverse correlation with disease activity score 28 (DAS28) and plasma TNF-alpha level. Similar negative correlations were found between disease activity and Tim-3 levels on CD4(+) T, CD8(+) T and NKT cells. Consistently, Tim-3 expression on CD3(+) T cells was further increased in patients with disease remission after treatment. Tim-3 expression on CD8(+) T and NKT cells negatively correlates with plasma TNF-a. Our results suggest that Tim-3 might participate in the proceeding of RA by its negative regulation on various T cell subsets. Tim-3 might be a potential new marker for assessing severity of RA. (C) 2010 Elsevier Inc. All rights reserved.
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