Journal
CLINICAL IMMUNOLOGY
Volume 135, Issue 1, Pages 12-25Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2009.12.005
Keywords
HCV; HIV-1; Innate immunity; IFN alpha; Chronic immune activation
Categories
Funding
- Swedish Research Council
- Swedish International Development Agency
- Swedish Foundation for Strategic Research
- Swedish Cancer Foundation
- Karolinska Institutet
- Karolinska University Hospital
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Innate immune responses are critical in the defense against viral infections. NK cells, myeloid and plasmacytoid dendritic cells, and invariant CD1d-restricted NKT cells mediate both effector and regulatory functions in this early immune response. In chronic uncontrolled viral infections such as HCV and HIV-1, these essential immune functions are compromised and can become a double edged sword contributing to the immunopathogenesis of viral disease. In particular, recent findings indicate that innate immune responses play a central role in the chronic immune activation which is a primary driver of HIV-1 disease progression. HCV/HIV-1 co-infection is affecting millions of people and is associated with faster viral disease progression. Here, we review the role of innate immunity and chronic immune activation in HCV and HIV-1 infection, and discuss how mechanisms of innate immunity may influence protection as well as immunopathogenesis in the HCV/HIV-1 co-infected human host. (C) 2009 Elsevier Inc. All rights reserved.
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