Journal
CLINICAL IMMUNOLOGY
Volume 132, Issue 2, Pages 184-194Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2009.04.012
Keywords
Apoptosis; Contact hypersensitivity; Galectin-9; Psoriasis; Regulatory T cells; Th17; Tim-3
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Tim-3 is a cell surface molecule preferentially expressed in Th1 and Th17 cells. Galectin-9 is a ligand for Tim-3 and the binding of gatectin-9 to Tim-3 induces apoptosis. We recently developed a stable form of gatectin-9 (sGal-9) by partial deletion of the linker peptide. In this study, we characterized the therapeutic effects of sGal-9 on inflammatory reactions in contact hypersensitivity and IL-23-induced psoriatic mouse models. In contact hypersensitivity in mice, the ear swelling response was suppressed by sGal-9. In vitro treatment with sGal-9 resulted in cell apoptosis of CD4, CD8, and hepatic NK cells. sGal-9-treated mice had decreased IFN-gamma- and IL-17-producing T cells. Similarly, sGal-9 reduced epidermal thickness and dermal cellular infiltrate levels in IL-23-induced psoriasis-like skin inflammation. This was accompanied by decreased skin lesion levels of IL-17 and IL-22. sGal-9 maybe a unique and useful therapeutic tool. for the treatment of Th1- and/or Th17-mediated skin inflammation. (C) 2009 Elsevier Inc. All rights reserved.
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