Journal
CLINICAL IMMUNOLOGY
Volume 133, Issue 2, Pages 228-237Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2009.07.003
Keywords
Neonate; Newborn; Innate immunity; Toll-like receptor; Infection
Categories
Funding
- Netherlands Asthma Foundation [3.2.07.001]
- WKZ Research Fund [2004.02]
- Alexandre Suerman Foundation
- Catharijne Stichting
Ask authors/readers for more resources
Newborns are highly susceptible to infectious diseases, which may be due to impaired immune responses. This study aims to characterize the ontogeny of neonatal TLR-based innate immunity during the first month of life. Cellularity and Toll-like receptor (TLR) agonist-induced cytokine production were compared between cord blood obtained from healthy neonates born after uncomplicated gestation and delivery (n = 18), neonatal venous blood obtained at the age of one month (n = 96), and adult venous blood (n=17). Cord blood TLR agonist-induced production of the Th1-polarizing cytokines IL-12p70 and IFN-alpha was generally impaired, but for TLR3, 7 and 9 agonists, rapidly increased to adult levels during the first month of life. In contrast, TLR4 demonstrated a slower maturation, with low LPS-induced IL-12p70 production and high IL-10 production up until the age of one month. Polarization in neonatal cytokine responses to LIPS could contribute to neonatal susceptibility to severe bacterial infection. (C) 2009 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available