Journal
CLINICAL IMMUNOLOGY
Volume 131, Issue 2, Pages 277-287Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2008.11.006
Keywords
AIED; HIV Gag p24 responses; Dual color ELISPOT; HIV viremia
Categories
Funding
- National Institutes of Health [AI043261-04]
- Reseau du SIDA et Maladies Infectieuses du Fonds de la Recherche en Sante du Quebec (FRSQ)
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HIV-specific immune responses in acute infection early disease (AIED) may be effective at controlling viral replication and in establishing viral toad (VL) set point. However, evidence correlating the function and specificity of these responses with the VL set point is lacking. To address this issue, we screened cells from 59 treatment-naive HIV infected individuals (33 in AIED and 26 progressors) for responses to the entire HIV proteome using a dual color ELISPOT assay detecting 3 functional lymphocyte populations: single IFN-gamma, dual IFN-gamma/IL-2 and single IL-2 secreting cells. Responses characterized by dual secreting cells contributed more to the HIV specific response in AIED versus chronic infection. Of responses directed to individual HIV gene products the magnitude and breadth of only Gag p24-specific responses for the 3 functional subsets were associated with lower concurrent or set point VL. Therefore the early appearance of broader and more intense Gag-p24-specific responses may be a determinant of subsequent VL. (C) 2008 Elsevier Inc. Alt rights reserved.
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