Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 46, Pages 13748-13752Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201506909
Keywords
asymmetric catalysis; cyclopropyl ketones; nucleophiles; ring opening; scandium catalysts
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Funding
- National Natural Science Foundation of China [21172151, 21290182, 21321061]
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A highly efficient asymmetric ring-opening reaction of cyclopropyl ketones with a broad range of thiols, alcohols and carboxylic acids has been first realized by using a chiral N,N'-dioxide-scandium(III) complex as catalyst. The corresponding sulfides, ethers, and esters were obtained in up to 99% yield and 95% ee. This is also the first example of one catalytic system working for the ring-opening reaction of donor-acceptor cyclopropanes with three different nucleophiles, let alone in an asymmetric version.
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