Journal
CLINICAL IMAGING
Volume 37, Issue 4, Pages 631-636Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.clinimag.2013.02.001
Keywords
Iron; Magnetic resonance imaging; Parkinson's disease
Funding
- Alfred Kordelin Foundation
- Tampere University Hospital
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We studied nonheme iron in Parkinson's disease (PD) using clinically available MRI in 36 patients and 21 healthy volunteers. The subjects underwent thorough clinical investigation, including 3-T MRI. Quantitative R2* was able to reflect symptoms of PD. In addition, the clinically used susceptibility-weighted imaging differentiated between controls and patients, whereas T-2-weighted imaging did not. Disease-related changes were present not only in substantia nigra but also in globus pallidus. Such changes are associated with neurodegeneration, reflecting the severity of motor impairment. (c) 2013 Elsevier Inc. All rights reserved.
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