Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 52, Pages 15884-15887Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201507444
Keywords
allylboration; boron homologation; diastereoselectivity; methylenecyclobutanes; one-pot reactions
Categories
Funding
- Chemical Industry Fund (FCI Liebig-fellowship)
Ask authors/readers for more resources
A highly diastereoselective synthesis of methylene-cyclobutanes possessing a quaternary stereocenter is reported, in which boron homologation of an easily-generated cyclobutenylmetal species is performed, followed by an allylation reaction. Combining three steps in a one-pot process further optimized the method, which afforded the expected adducts in excellent yields and stereoselectivity, starting from commercially available 4-bromobutyne.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
