Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 37, Pages 10971-10974Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201503652
Keywords
aptamers; GFP; molecular evolution; nucleic acids; SELEX
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Funding
- German Research Council (Deutsche Forschungsgemeinschaft) [Ma 3442/4-1]
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A novel and versatile method has been developed for modular expansion of the chemical space of nucleic acid libraries, thus enabling the generation of nucleobase-modified aptamers with unprecedented recognition properties. Reintroduction of the modification after enzymatic replication gives broad access to many chemical modifications. This wide applicability, which is not limited to a single modification, will rapidly advance the application of invitro selection approaches beyond what is currently feasible and enable the generation of aptamers to many targets that have so far not been addressable.
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