Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 28, Pages 8119-8123Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201500867
Keywords
biocatalysis; hydrogel; nanostructures; peptides; self-assembly
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Funding
- European Research Council under the European Union's Seventh Framework Programme (FP7) EMERgE/ERC [258775]
- Linn Products Ltd.
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Structural adaption in living systems is achieved by competing catalytic pathways that drive assembly and disassembly of molecular components under the influence of chemical fuels. We report on a simple mimic of such a system that displays transient, sequence-dependent formation of supramolecular nanostructures based on biocatalytic formation and hydrolysis of self-assembling tripeptides. The systems are catalyzed by -chymotrypsin and driven by hydrolysis of dipeptide aspartyl-phenylalanine-methyl ester (the sweetener aspartame, DF-OMe). We observed switch-like pathway selection, with the kinetics and consequent lifetime of transient nanostructures controlled by the peptide sequence. In direct competition, kinetic (rather than thermodynamic) component selection is observed.
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