Journal
JOURNAL OF LUMINESCENCE
Volume 161, Issue -, Pages 47-53Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jlumin.2014.12.050
Keywords
Simple synthesis; CdTe quantum dots; Norfloxacin lactate; Fluorescence quenching
Categories
Funding
- National Natural Science Foundation of China [21107037, 21176107, 21174057, 21277063, 21346004, 21407057, 21407064]
- National Basic Research Program of China (973 Program) [2012CB821500]
- Natural Science Foundation of Jiangsu Province [BK2011461, BK2011514, BK20140535]
- Ph.D. Innovation Programs Foundation of Jiangsu Province [KYLX_1032]
- China Postdoctoral Science Foundation [2013M530240, 2014M561595]
- Postdoctoral Science Foundation [1202002B, 1401108C]
- Programs of Senior Talent Foundation of Jiangsu University [12JDG090]
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In this study, a simple and effective fluorometry method has been developed and used for the determination of Norfloxacin lactate (NOR-L) by the fluorescence quenching of thioglycolic acid (TGA)-coated CdTe quantum dots (QDs). The TGA-CdTe QDs were obtained in a simple way without precursor preparation, heating, pH adjustment and N-2 protection. The CdTe QDs were characterized by TEM, UV-vis spectrophotometer and spectrofluorometer. Meanwhile, spectrofluorometer was used to evaluation of simple, convenient and highly sensitive determination of NOR-L. After the experimental conditions were optimized, a good linear relationship was obtained from 0.1-100 mu g/mL with the coefficient of determination (0.99342) and the limit of detection (LOD) was 0.031 mu g/mL. Moreover, a possible quenching mechanism was investigated and the CdTe QDs were also successfully used to confirm the NOR-L in pharmaceutical formations. The proposed method is rapid, simple, and applied. (C) 2015 Published by Elsevier B.V.
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