Journal
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
Volume 9, Issue 12, Pages 1044-1049Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cgh.2011.08.014
Keywords
Clostridium difficile; Transplantation; Microbiota; Fecal Enema; Recurrent Infection; Diarrhea
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Funding
- Minnesota Medical Foundation
- NIH [1R21AI091907]
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Clostridium difficile infection is increasing in incidence, severity, and mortality. Treatment options are limited and appear to be losing efficacy. Recurrent disease is especially challenging; extended treatment with oral vancomycin is becoming increasingly common but is expensive. Fecal microbiota transplantation is safe, inexpensive, and effective; according to case and small series reports, about 90% of patients are cured. We discuss the rationale, methods, and use of fecal microbiota transplantation.
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