Journal
ACS NANO
Volume 9, Issue 1, Pages 860-868Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn506544b
Keywords
self-assembly; supramolecular chemistry multidomain peptide; angiogenesis
Categories
Funding
- Robert A. Welch Foundation [C1557]
- National Institute of Health [R01 DE021798, F32 DE023696]
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Major limitations of current tissue regeneration approaches using artificial scaffolds are fibrous encapsulation, lack of host cellular infiltration, unwanted immune responses, surface degradation preceding biointegration, and artificial degradation byproducts. Specifically, for scaffolds larger than 200-500 mu m, implants must be accompanied by host angiogenesis in order to provide adequate nutrient/waste exchange in the newly forming tissue. In the current work, we design a peptide-based self-assembling nanofibrous hydrogel containing cell-mediated degradation and proangiogenic moieties that specifically address these challenges. This hydrogel can be easily delivered by syringe, is rapidly infiltrated by cells of hematopoietic and mesenchymal origin, and rapidly forms an extremely robust mature vascular network. Scaffolds show no signs of fibrous encapsulation and after 3 weeks are resorbed into the native tissue. These supramolecular assemblies may prove a vital paradigm for tissue regeneration and specifically for ischemic tissue disease.
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