Journal
CLINICAL COLORECTAL CANCER
Volume 7, Issue 5, Pages 331-337Publisher
CIG MEDIA GROUP, LP
DOI: 10.3816/CCC.2008.n.044
Keywords
albumin; cachexia; C-reactive protein; cytokine; Glasgow Prognostic Score; single-nucleotice polymorphism
Categories
Funding
- Cancer Institute New South Wales
Ask authors/readers for more resources
We aim to confirm the prognostic value of an inflammation-based prognostic score (the Glasgow Prognostic Score [GPS]) in advanced colorectal cancer,to explore a predictive pattern of plasma cytokines and their gene polymorphisms for clinical outcome, and to investigate which cytokines contribute to GPS. Inflammatory markers were measured at baseline in 52 patients with stage IV colorectal cancer. Germline DNA was genotyped for interleukin (IL)-1 beta-511, IL-1 beta +3954, IL-6-174, TNF-alpha-308, IL-10-1082, and IL-10-592 using Sequenome mass spectrometry-based genotyping technology. Toxicity was graded by the National Cancer Institute Common Toxicity Criteria version 2.0. Response was assessed by the Response Evaluation Criteria in Solid Tumors. Glasgow Prognostic Score, carcinoembryonic antigen and hypoalbuminemia were predictive of overall survival (OS). Hypoalbuminemia (<= 35 g/L) and GPS were predictive of toxicity; GPS 2 was predictive of increased grade 2/3 toxicity compared with patients with a GPS of 0 or 1 (P < .05). Interleukin-10-592AA and IL-10-1082CC predicted for OS (P < .05). Elevated levels of circulating IL-4 and soluble glycoprotein 130 (sgp 130) were associated with increased grade 2/3 toxicity. Significantly elevated levels of IL-6 and sgp 130 were observed in patients with a GPS of 2 (P < .05). In this patient group, inflammatory markers predict for clinical outcome. This could improve prognostication and allow for intervention strategies to reduce tumor-associated inflammation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available