Journal
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Volume 48, Issue 5, Pages 707-711Publisher
WALTER DE GRUYTER & CO
DOI: 10.1515/CCLM.2010.142
Keywords
adiponectin; anthropometric data; body composition; leptin; pubertal children
Categories
Funding
- Fondo de Investigacion Sanitaria [FIS 08/1189]
- Fundacion de Investigacion Medica Mutua Madrilena
- Fondo de Investigacion Sanitaria
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Background: Adipocytokines play an important role in controlling energy homeostasis, and in various metabolic processes related to obesity. The aim of this study was to describe serum leptin and adiponectin concentrations in a sample of pubertal Spanish children and to evaluate their association with anthropometric parameters and body composition. Methods: The study included 833 pubertal boys and girls. Serum leptin and adiponectin concentrations were determined by ELISA. Results: Leptin concentrations were significantly higher (p<0.0001) in obese or overweight (OW) children compared with children with normal weight (NW). Adiponectin was significantly lower (p<0.01) in obese or OW girls compared with girls of NW, although these findings were not the same for boys. Weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist to hip ratio were significantly correlated (p<0.01) with leptin concentrations in both genders. Correlation of leptin with fat mass and % fat mass was strong, particularly in boys. The association of adiponectin concentrations with anthropometric variables was weaker in both genders. No significant correlations were found between adiponectin concentrations and fat mass or % fat mass. Conclusions: In summary, our study showed that, in pubertal children, leptin is related to weight, BMI, WC and HC and correlates even more strongly with % fat mass. However, adiponectin was weakly related to anthropometric variables and was not correlated with body fat. Clin Chem Lab Med 2010;48:707-11.
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