Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 20, Pages 5952-5956Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201500286
Keywords
cancer; carbohydrates; nanoparticles; receptors; synthesis design
Categories
Funding
- CNRS
- ANR P2N - NanoptPDT
- BQR University of Montpellier 1
- Ligue Nationale Contre le Cancer
- FEDER region Languedoc Roussillon [41470]
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The development of personalized and non-invasive cancer therapies based on new targets combined with nanodevices is a major challenge in nanomedicine. In this work, the over-expression of a membrane lectin, the cation-independent mannose 6-phosphate receptor (M6PR), was specifically demonstrated in prostate cancer cell lines and tissues. To efficiently target this lectin a mannose-6-phosphate analogue was synthesized in six steps and grafted onto the surface of functionalized mesoporous silica nanoparticles (MSNs). These MSNs were used for in vitro and ex vivo photodynamic therapy to treat prostate cancer cell lines and primary cell cultures prepared from patient biopsies. The results demonstrated the efficiency of M6PR targeting for prostate cancer theranostic.
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