Journal
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
Volume 38, Issue 12, Pages 1223-1229Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10826076.2015.1032418
Keywords
drug delivery systems; tamoxifen; RP-HPLC quantification; analytical development and validation; in vitro release profile; hybrid pegylated micelles
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP
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Studies of in vitro release profiles are important during the development of drug delivery systems. This article describes the development and validation of a RP-HPLC method for the quantification of drug released from tamoxifen-loaded DSPE-PEG(2000)/TPGS micelles and the determination of the best dissolution medium and apparatus for this assay. The method showed specificity, linearity, precision, accuracy, and robustness for the parameters evaluated (range 0.25-20.0 mu gmL(-1)). The best dissolution medium was 1.0molL(-1) sodium salicylate, pH 7.4, and the most suitable apparatus was a PVC tube with one end covered with a dialysis membrane. This method was shown to be useful for tamoxifen quantification in in vitro release studies.
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