Journal
CLINICAL CANCER RESEARCH
Volume 20, Issue 7, Pages 1891-1899Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-13-2830
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Funding
- Cancer Institute (INCa)
- Association pour la Recherche sur le Cancer (ARC)
- AP-HP-Programme Hospitalier de Recherche Clinique (PHRC)
- SIRICCARPEM
- INCA [Transla13-142]
- Canceropole Ile-de-France, Ville de Paris, University of Medicine, and Pharmacy Gr.T.Popa Iasi, Romania [P.O.S.D.R.U./88/1.5/S/58965]
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Purpose: To determine whether the tumor immune infiltrate, as recently evaluated with the Immunoscore methodology, could be a useful prognostic marker in patients with rectal cancers. Experimental design: The influence of the immune infiltrate on patient's outcome was investigated in patients with or without preoperative chemoradiation therapy (pCRT). The density of total (CD3(+)) and cytotoxic (CD8(+)) T lymphocytes was evaluated by immunohistochemistry and quantified by a dedicated image analysis software in surgical specimens of patients with rectal cancer (n=111) who did not receive pCRT and in tumor biopsies performed before pCRT from additional 55 patients. The results were correlated with tumor recurrence, patient's survival, and response to pCRT. Results: The densities of CD3(+) and CD8(+) lymphocytes and the associated Immunoscore (from 10 to 14) were significantly correlated with differences in disease-free and overall survival (HR, 1.81 and 1.72, respectively; all P < 0.005). Cox multivariate analysis supports the advantage of the Immunoscore compared with the tumor-node-metastasis (TNM) staging in predicting recurrence and survival (all P < 0.001). Lymph node ratio added information in a prognostic model (all P < 0.05). In addition, high infiltration of CD3(+) and CD8(+) lymphocytes in tumor biopsies was associated with downstaging of the tumor after pCRT (CD3(+) cells; Fisher exact test P=0.01). Conclusions: The Immunoscore could be a useful prognostic marker in patients with rectal cancer treated by primary surgery. The determination of the immune infiltrate in biopsies before treatment could be a valuable information for the prediction of response to pCRT. (C) 2014 AACR.
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