Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 30, Pages 8791-8794Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201502860
Keywords
asymmetric catalysis; hydrogenation; iridium; ketoesters; spiro ligands
Categories
Funding
- National Natural Science Foundation of China
- National Basic Research Program of China [2012CB821600]
- Ministry of Education of China [B06005]
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The chiral tridentate spiro P-N-S ligands (SpiroSAP) were developed, and their iridium complexes were prepared. Introduction of a 1,3-dithiane moiety into the ligand resulted in a highly efficient chiral iridium catalyst for asymmetric hydrogenation of -alkyl--ketoesters, producing chiral -alkyl--hydroxyesters with excellent enantioselectivities (95-99.9% ee) and turnover numbers of up to 355000.
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