Journal
CLINICAL CANCER RESEARCH
Volume 14, Issue 3, Pages 627-632Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-07-2220
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Funding
- NCI NIH HHS [CA 80606, CA40042, CA 29243] Funding Source: Medline
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The tumor microenvironment plays a central role in cancer progression and metastasis. Within this environment, cancer cells respond to a host of signals including growth factors and chemotactic factors, as well as signals from adjacent cells, cells in the surrounding stroma, and signals from the extracellular matrix. Targeting the pathways that mediate many of these signals has been a major goal in the effort to develop therapeutics.
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