Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 98, Issue 4, Pages 497-502Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.2MR1114-573R
Keywords
sensors; channels; NADPH oxidase; neutrophil activation
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Funding
- National Institute of Allergy and Infectious Diseases U.S. National Institutes of Health [RO1 AI065495, RO1 AI068150]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [K12-HD000850]
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Calcium signals in neutrophils are initiated by a variety of cell-surface receptors, including formyl peptide and other GPCRs, FcRs, and integrins. The predominant pathway by which calcium enters immune cells is termed SOCE, whereby plasmamembrane CRAC channels allow influx of extracellular calcium into the cytoplasm when intracellular ER stores are depleted. The identification of 2 key families of SOCE regulators, STIM calcium sensors and ORAI calcium channels, has allowed for genetic manipulation of SOCE pathways and provided valuable insight into the molecularmechanism of calcium signaling in immune cells, including neutrophils. This review focuses on our current knowledge of the molecules involved in neutrophil SOCE and how study of these molecules has further informed our understanding of the role of calcium signaling in neutrophil activation.
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