Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 98, Issue 5, Pages 727-737Publisher
WILEY
DOI: 10.1189/jlb.3RU1114-563R
Keywords
lung; neutrophil; homing; T cells; microbiome
Categories
Funding
- Australian National Health and Medical Research Council
- Hunter Medical Research Institute
- Canadian Institutes of Health Research, University of Newcastle
Ask authors/readers for more resources
Inflammatory bowel disease is associated with a number of comorbidities that arise at extraintestinal sites, including the lung. Pulmonary manifestations reported in inflammatory bowel disease include bronchiectasis, chronic bronchitis and importantly, a range of subclinical respiratory abnormalities that are often overlooked in routine clinical evaluation. Whereas evidence for the pulmonary manifestations of Inflammatory bowel disease is increasing, little is known about the immunologic and physiologic mechanisms regulating cross-talk between the gut and lung during disease. This review examines reported lung involvement in Inflammatory bowel disease and discusses the possible immune pathways that underlie pulmonary pathologies. These mechanisms include dysfunctional immune-cell homing, systemic inflammation, and microbial dysbiosis; all of which may contribute to Inflammatory bowel disease-induced pulmonary inflammation. These mechanisms are discussed in the context of our current knowledge of the shared mucosal immune system and the immunology of Inflammatory bowel disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available