Journal
CLINICAL BIOCHEMISTRY
Volume 45, Issue 1-2, Pages 49-53Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2011.10.010
Keywords
Depression; Neuroprotection; Treatment; Uric acid
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Funding
- Technology Project of the Guangdong Province China [2008B030301068]
- Sun Yat-Sen University [2008A506]
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Objective: This study was designed to investigate the correlation between serum uric acid (UA) levels and the clinical characteristics of depression. Design and methods: The serum HA levels were measured in 124 patients with depression, 660 patients with different types of other mental disorders (OMD) and 42 healthy subjects. Clinical characteristics of depression and OMD were also investigated. Results: Depressive patients (271.97 +/- 77.50 mu mol/L) had significantly lower UA levels than those with delirium, dementia, amnesia and other cognitive disorders (339.95 +/- 141.74 mu mol/L, P = 0.004), substances related disorders (359.61 +/- 125.02 mu mol/L, P = 0.022), schizophrenia (341.03 +/- 106.84 mu mol/L, P = 0.000), schizoaffective disorder (336.78 +/- 155.49 mu mol/L, P = 0.024), bipolar disorder (323.04 +/- 108.70 mu mol/L, P = 0.008) and the healthy control group (315.76 +/- 87.50 mu mol/L, P = 0.012). We also found that the HA levels of depressive patients normalised after a five week treatment with antidepressants. Conclusion: Our data suggested that a lowered HA level is another characteristic of depression. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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