Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 97, Issue 6, Pages 1133-1137Publisher
WILEY
DOI: 10.1189/jlb.4AB1113-607RR
Keywords
NADPH oxidase; chronic granulomatous disease; phagocytosis; Nox2; p22(phox)
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Funding
- Hungarian Research Fund [OTKA K106138, K81676, K109444]
- National Office for Research and Technology [OMFB-01680/2009]
- Lendulet grant from the Hungarian Academy of Sciences
- TAMOP VED-ELEM project [4.2.2.A-11/1/KONV-2012-0023]
- European Social Fund
- European Regional Development Fund
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Regulated production of ROS is mainly attributed to Nox family enzymes. In neutrophil granulocytes and macrophages, Nox2 has a crucial role in bacterial killing, and the absence of phagocytic ROS production leads to the development of CGD. Expression of Nox2 was also described in B lymphocytes, where the role of the enzyme is still poorly understood. Here, we show that peritoneal B cells, which were shown recently to possess phagocytic activity, have a high capacity to produce ROS in a Nox2-dependent manner. In phagocytosing B cells, intense intraphagosomal ROS production is detected. Finally, by studying 2 animal models of CGD, we demonstrate that phagocyte oxidase-deficient B cells have a reduced capacity to kill bacteria. Our observations extend the number of immune cell types that produce ROS to kill pathogens.
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