Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 97, Issue 5, Pages 859-871Publisher
WILEY
DOI: 10.1189/jlb.2RU0814-388R
Keywords
EPA; DHA; Fc epsilon RI; lipid rafts; eicosanoid
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Mast cells are known to play a vital role in the development of inflammation in allergic responses. Recent studies have indicated that mast cell activation could be modulated by n-3 PUFAs, which have a wide range of well-documented health benefits. In our review, we summarize the recent findings and potential mechanisms of the effect of n-3 PUFAs on mast cell activation. This knowledge could provide new strategies for the development of therapeutic interventions for diseases mediated by mast cells.
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