Journal
CLINICAL BIOCHEMISTRY
Volume 44, Issue 13, Pages 1094-1096Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2011.06.081
Keywords
Orthopedics; Knee; Osteoarthritis; Disease severity; Kellgren-Lawrence grade; Lectin-like oxidized low-density lipoprotein receptor-1; Transmembrane glycoprotein; Serum; Synovial fluid; Biochemical marker
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Objectives: This study was aimed to measure soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels in serum and synovial fluid (SF) of knee osteoarthritis (OA) patients and to investigate the correlation between sLOX-1 levels and the disease severity. Design and methods: Two hundred and sixteen OA patients and 83 healthy controls were enrolled in this study. All OA patients were scored for Kellgren-Lawrence (KL) grade (0-4). The sLOX-1 levels were measured by enzyme-linked immunosorbent assay (ELISA). Results: In OA patients, the mean sLOX-1 levels in SF were markedly lower than those in paired serum samples (P<0.01). The SF sLOX-1 levels increased with higher KL grade (P<0.01) and were significantly correlated with disease severity (r=0.324, P<0.01). SF sLOX-1 level was the independent factor for predicting the disease severity of OA (beta: 0.281, 95%CI: 0.145-0.396). Conclusions: SF sLOX-1 levels were independently and positively associated with disease severity in knee OA. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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