Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 98, Issue 3, Pages 333-345Publisher
WILEY
DOI: 10.1189/jlb.3RI0315-095R
Keywords
autoimmune disease; DR3
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Funding
- National Institute of Arthritis and Musculoskeletal and Skin Diseases of the U.S. National Institutes of Health
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Originally described in 2002 as a T cell-costimulatory cytokine, the tumor necrosis factor family member TNF-like factor 1A (TL1A), encoded by the TNFSF15 gene, has since been found to affect multiple cell lineages through its receptor, death receptor 3 (DR3, encoded by TNFRSF25) with distinct cell-type effects. Genetic deficiency or blockade of TL1A-DR3 has defined a number of disease states that depend on this cytokine-receptor pair, whereas excess TL1A leads to allergic gastrointestinal inflammation through stimulation of group 2 innate lymphoid cells. Noncoding variants in the TL1A locus are associated with susceptibility to inflammatory bowel disease and leprosy, predicting that the level of TL1A expression may influence host defense and the development of autoimmune and inflammatory diseases.
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