Post-methionine load test: A more sensitive tool to reveal hyperhomocystememia in Alzheimer patients?

Objective: To identify the real number of hyperhomocysteinemic Alzheimer's patients who may benefit from homocysteine-lowering therapy. Methods: Basal and post-methionine load homocysteine levels were assessed by rp-HPLC system. Results: PML test revealed twice as many hyperhomocysteinemic AD subjects with respect to the fasting analysis. Conclusion: PML test resulted useful in detecting higher number of hyperhomocysteinemic AD patients who may have the chance of an early folate treatment. (c) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.