Journal
CLINICAL AND VACCINE IMMUNOLOGY
Volume 20, Issue 8, Pages 1338-1340Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00275-13
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- Intramural Research Program of the Center for Biologics Evaluation and Research, Food and Drug Administration
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The staphylococcal adhesin clumping factor A (ClfA) has a variant amino acid sequence, generating the potential for alterations in epitope structure and immunogenicity of this vaccine candidate. We demonstrated for two recombinant ClfA(40-531) (a slightly truncated version of the fibrinogen-binding domain of ClfA containing amino acids 40 to 531) genetic variants that strain-specific epitopes are immunodominant. This work indicates that immune responses elicited by ClfA may, at least in part, be dependent on the strain of origin of the ClfA.
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