3.9 Article

Increased Serum MicroRNA-155 Level Associated with Nonresponsiveness to Hepatitis B Vaccine

Journal

CLINICAL AND VACCINE IMMUNOLOGY
Volume 20, Issue 7, Pages 1089-1091

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00044-13

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Funding

  1. Natural Science Foundation of Guangdong [s2011040002978]
  2. Guangdong Medical Research Foundation [A2012422]
  3. Science Foundation of Dongguan [201010815214]

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We compared the serum levels of microRNA-155 (miR-155) between subjects with normal response to hepatitis B vaccine and nonresponders. Results showed that serum expression of miR-155 was significantly higher in nonresponders than in responders (6.40 versus 2.55; Z = 2.125, P = 0.034), suggesting that overexpression of miR-155 is correlated with nonresponsiveness to hepatitis B vaccine.

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