Journal
CLINICAL AND VACCINE IMMUNOLOGY
Volume 20, Issue 3, Pages 363-368Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00438-12
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Funding
- Ligue Contre le Cancer (Comites de l'Indre et Loire, du Cher, de l'Indre, du Maine et Loire, et de la Sarthe)
- University of Ferrara (FAR project)
- Fondazione Umberto Veronesi (Italy)
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Six new human polyomaviruses have been identified since 2008 (Merkel cell polyomavirus [MCPyV], human polyomavirus 6 [HPyV6], HPyV7, HPyV9, trichodysplasia spinulosa polyomavirus [TSPyV], and Malawi polyomavirus [MWPyV]). The presence of specific antibodies against MCPyV, HPyV6, HPyV7, HPyV9, and TSPyV in 828 Italian subjects aged 1 to 100 years was investigated by virus-like particle-based enzyme-linked immunosorbent assays (ELISAs). The findings indicate that all of these new polyomaviruses circulate widely in humans, with seroprevalences in adulthood ranging from 39.4% for HPyV9 to 87.1% for MCPyV, and that primary exposure is most intense in childhood, with the exception of HPyV7 and HPyV9, for which the sero-prevalence increased throughout life. The proportion of subjects with high antibody titers was found to increase with age for MCPyV and to decrease with age for TSPyV.
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