Journal
CLINICAL AND VACCINE IMMUNOLOGY
Volume 19, Issue 6, Pages 842-848Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00037-12
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Funding
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases [U01 AI058935, R03 AI063079, U01 AI077883]
- Fogarty International Center [TW005572, TW007409, TW07144]
- American Recovery and Reinvestment Act (ARRA) FIC [TW05572]
- Harvard Initiative for Global Health
- Howard Hughes Medical Institute
- Vanderbilt University [R24 TW007988]
- American Relief and Recovery Act
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Vibrio cholerae O1 causes cholera, a dehydrating diarrheal disease. We have previously shown that V. cholerae-specific memory B cell responses develop after cholera infection, and we hypothesize that these mediate long-term protective immunity against cholera. We prospectively followed household contacts of cholera patients to determine whether the presence of circulating V. cholerae O1 antigen-specific memory B cells on enrollment was associated with protection against V. cholerae infection over a 30-day period. Two hundred thirty-six household contacts of 122 index patients with cholera were enrolled. The presence of lipopolysaccharide (LPS)-specific IgG memory B cells in peripheral blood on study entry was associated with a 68% decrease in the risk of infection in household contacts (P = 0.032). No protection was associated with cholera toxin B subunit (CtxB)-specific memory B cells or IgA memory B cells specific to LPS. These results suggest that LPS-specific IgG memory B cells may be important in protection against infection with V. cholerae O1.
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