Journal
CLINICAL AND VACCINE IMMUNOLOGY
Volume 19, Issue 6, Pages 970-973Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00068-12
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Funding
- Simian Vaccine Evaluation Unit (SVEU) of the Division of AIDS
- European Community [201433]
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Female rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous prime-boost schedules. The results show that in rhesus macaques only the sequential intranasal and intramuscular administration of HIV-VLPs, and not the intranasal alone, is able to elicit humoral immune response at the systemic as well as the vaginal level.
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