3.9 Article

Correlation between Serum and Plasma Antibody Titers to Mycobacterial Antigens

Journal

CLINICAL AND VACCINE IMMUNOLOGY
Volume 18, Issue 1, Pages 173-175

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00325-10

Keywords

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Funding

  1. National Institutes of Health (NIH/NIAID) [AI-067665, AI-033774, AI-052733, HL-059842, AI-033146]
  2. Center for AIDS Research [AI-51519]
  3. Albert Einstein College of Medicine
  4. Clinical Translational Science Institute at the New York University School of Medicine [NCRR 1UL1RR029893]
  5. Howard Hughes Medical Institute
  6. Aeras Global TB Vaccine Foundation
  7. Graduate Division of Biomedical Sciences, Albert Einstein College of Medicine
  8. NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR029893] Funding Source: NIH RePORTER
  9. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL059842] Funding Source: NIH RePORTER
  10. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [K23AI067665, P30AI051519, R01AI033774, R01AI052733] Funding Source: NIH RePORTER

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The ability to utilize serum or plasma samples interchangeably is useful for tuberculosis (TB) serology. We demonstrate a strong correlation between antibody titers to several mycobacterial antigens in serum versus plasma from HIV-infected and non-HIV-infected TB and non-TB patients (r = 0.99 to 0.89; P < 0.0001). Plasma and serum can be used interchangeably in the same antibody detection assays.

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