Journal
CLINICAL AND VACCINE IMMUNOLOGY
Volume 17, Issue 2, Pages 304-306Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00353-09
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- Military Infectious Diseases Research Program [S0082_06_NM]
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We evaluated a novel psoralen-inactivated dengue virus type 1 (DENV-1) vaccine candidate in Mus musculus mice. Mice received intradermal alum or 5 to 10 ng of psoralen-inactivated virus. Anti-DENV-1 neutralizing antibody was detectable in 10/11 mice receiving a 10-ng dose at 90 days. Psoralen-inactivated DENV-1 is immunogenic in mice.
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