3.9 Article

Efficacy of a Genetically Engineered Candida albicans tet-NRG1 Strain as an Experimental Live Attenuated Vaccine against Hematogenously Disseminated Candidiasis

Journal

CLINICAL AND VACCINE IMMUNOLOGY
Volume 16, Issue 3, Pages 430-432

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00480-08

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Funding

  1. National Institute of Allergy and Infectious Diseases [RO1AI064562, RO1AI063256]

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We report on the efficacy of the genetically engineered Candida albicans tet-NRG1 strain as an experimental live, attenuated vaccine against disseminated candidiasis in both immunocompetent and immunodeficient mice mostly dependent on T-cell immunity. This experimental vaccination model may represent an important tool to unravel the mechanisms of protective immunity during candidiasis.

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