Journal
CLINICAL AND VACCINE IMMUNOLOGY
Volume 16, Issue 3, Pages 430-432Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00480-08
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Funding
- National Institute of Allergy and Infectious Diseases [RO1AI064562, RO1AI063256]
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We report on the efficacy of the genetically engineered Candida albicans tet-NRG1 strain as an experimental live, attenuated vaccine against disseminated candidiasis in both immunocompetent and immunodeficient mice mostly dependent on T-cell immunity. This experimental vaccination model may represent an important tool to unravel the mechanisms of protective immunity during candidiasis.
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