Journal
CLINICAL AND VACCINE IMMUNOLOGY
Volume 15, Issue 10, Pages 1497-1504Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00166-08
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Funding
- Istituto Superiore di Sanita
- Italian Concerted Action on HIV-AIDS Vaccine Development (ICAV)
- Ministero dell'Istruzione, dell'Universita e della Ricerca Project
- Associazione Italiana per la Ricerca sul Cancro
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The efficiency of cross-presentation of exogenous antigens by dendritic cells (DCs) would seem to be related to the level of antigen escape from massive degradation mediated by lysosomal proteases in an acidic environment. Here, we demonstrate that a short course of treatment with chloroquine in mice during primary immunization with soluble antigens improved the cross-priming of naive CD8(+) T lymphocytes in vivo. More specifically, priming of chloroquine-treated mice with soluble ovalbumin (OVA), OVA associated with alum, or OVA pulsed on DCs was more effective in inducing OVA-specific CD8(+) T lymphocytes than was priming of untreated mice. We conclude that chloroquine treatment improves the cross-presentation capacity of DCs and thus the size of effector and memory CD8(+) T cells during vaccination.
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