Journal
CLINICAL AND VACCINE IMMUNOLOGY
Volume 16, Issue 2, Pages 285-287Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00363-08
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Funding
- Pediatric Dengue Vaccine Initiative of the International Vaccine Institute [TR 03/04, TR16]
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Sera from patients involved in a Peruvian outbreak of dengue virus serotype 1 infection cross-neutralized the American genotype of dengue virus serotype 2 up to 100-fold more efficiently than they did the virulent Asian genotype of dengue virus serotype 2, as determined by a plaque reduction neutralization test (PRNT) with CV-1 fibroblasts modified to express human Fc gamma receptor CD32. The concordant preferential immune enhancement of the Asian genotype of dengue virus serotype 2 in human monocytes suggests that such a modification might strengthen the correlation between the PRNT titer and protection.
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