Journal
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Volume 41, Issue 12, Pages 986-994Publisher
WILEY
DOI: 10.1111/1440-1681.12313
Keywords
atorvastatin; glucose transporter 4; myocardial infarction
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Funding
- Institute of Cardiology Research Support Fund (FAPPIC)
- Research Support Foundation of Rio Grande do Sul (FAPERGS)
- Coordination for the Improvement of Higher Education Personnel (CAPES)
- Brazilian National Council for Scientific and Technological Development (CNPq)
- Fundacao de Apoio a Pesquisa do Estado de Sao Paulo (FAPESP) [2012/04831-1]
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Statins have a beneficial effect after myocardial infarction, but the relationship between glucose transporters and their use before the event has not yet been studied. We assessed the effects of atorvastatin treatment pre- and post-myocardial infarction on cardiovascular function and glucose transporter 4 (GLUT4) in the heart. Wistar-Kyoto rats were treated with 20 mg/kg atorvastatin or vehicle for 14 days before coronary artery occlusion surgery (myocardial infarction) or sham surgery. Echocardiographic evaluations were carried out 48 h after myocardial infarction (protocol A) and after 7 days (protocol B), when atorvastatin was also administered. Plasma inflammatory markers and GLUT4 in the heart were also evaluated. Animals were divided into the following groups: sham-operated and vehicle (C), myocardial infarction and vehicle (I), sham-operated and atorvastatin (CAt) and myocardial infarction and atorvastatin (IAt). After 48 h, myocardial infarction induced higher left ventricular fractional shortening in IAt versus I (similar to 60%, P = 0.036), and the ejection fraction was lower (protocol A similar to 37%; protocol B similar to 30%). Myocardial infarction was associated with a rise in plasma membrane GLUT4 after 48 h (similar to 40%, P < 0.001), and a reduction in GLUT4 after 7 days (I 25%; IAt 49%, P < 0.001). Atorvastatin treatment for 48 h after the infarction did not change GLUT4 expression, and after 7 days it had an additional negative effect on GLUT4 content (similar to 39%, P = 0.030). In conclusion, atorvastatin treatment pre- and post-myocardial infarction improved myocardial contractility after 48 h, but not after 7 days, and was not associated with an increase in GLUT4 expression.
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