Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 17, Pages 5192-5195Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201412494
Keywords
diazo compounds; molecular imprinting; iridium; living polymerization; ATRP
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Funding
- European Regional Development Fund ERDF under CPER
- European Commission (FP7 Marie Curie Actions, project CHE-BANA) [PITN-GA-2010-264772]
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Molecularly imprinted polymers (MIPs) are artificial receptors which can be tailored to bind target molecules specifically. A new method, using photoinitiated atom-transfer radical polymerization (ATRP) for their synthesis as monoliths, thin films and nanoparticles is described. The synthesis takes place at room temperature and is compatible with acidic monomers, two major limitations for the use of ATRP with MIPs. The method has been validated with MIPs specific for the drugs testosterone and S-propranolol. This study considerably widens the range of functional monomers and thus molecular templates which can be used when MIPs are synthesized by ATRP, as well as the range of physical forms of these antibody mimics, in particular films and lithographic patterns, and their post-functionalization from living chainends.
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