Hypoxia-inducible factor 1 activation from adipose protein 2-cre mediated knockout of von hippel-lindau gene leads to embryonic lethality

1. von Hippel-Lindau protein, an E3 ubiquitin ligase from the von Hippel-Lindau (Vhl) gene, inhibits the transcriptional activity of hypoxia-inducible factor 1a in cells. To gain insight into the hypoxia-inducible factor 1a signalling pathway in adipose tissue, a study was conducted to generate fat-specific Vhl knockout mice.