Journal
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Volume 38, Issue 12, Pages 834-845Publisher
WILEY
DOI: 10.1111/j.1440-1681.2011.05618.x
Keywords
chemical imaging; liver; magnetic resonance imaging contrast agents; X-ray fluorescence
Categories
Funding
- MIUR [RBIN04HC3S]
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1. Spatially resolved X-ray fluorescence (XRF) spectroscopy with synchrotron radiation is a technique that allows imaging and quantification of chemical elements in biological specimens with high sensitivity. In the present study, we applied XRF techniques at a macro and micro level to carry out drug distribution studies on ex vivo models to confirm the hepatobiliary disposition of the Gd-based magnetic resonance imaging contrast agent B22956/1.
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